Big with Mean Teeth Ghost is one of a number of ghosts that appear in the first intro. However, he is the only in the intro not have appeared in the pilot of the show, as he replaced Slimer. He has also appeared in many promotional items.
A medium-large sized creature with jagged teeth, small eyes, and a rather large forehead.
- On Cover RI of Ghostbusters Issue #15, the Big with Mean Teeth Ghost makes a non-canon cameo.
- The ghost makes a cameo on a special sketch cover of Ghostbusters #9