Brain Buster  is a computer game designed to stump players with difficult questions.
While shopping for a birthday present for Lawrence Tully at the Toy Tower, Ray Stantz saw Slimer playing with a Brain Buster and also suggested it. Louis Tully turned down the idea. Lawrence already owned two from Christmas. 
- On page 21 of Ghostbusters Volume 2 Issue #3, Brain Buster makes a non-canon cameo on the Toy Tower store front.
- ↑ Ray Stantz (2009). The Real Ghostbusters - "Busters in Toyland" (1990) (DVD ts. 04:53-04:55). Time Life Entertainment. Ray says: "Brain Buster computer?"
- ↑ Louis Tully (2009). The Real Ghostbusters - "Busters in Toyland" (1990) (DVD ts. 04:49-04:51). Time Life Entertainment. Louis says: "He got two for Christmas."