Dr. Strangedog's Mansion is an isolated estate in New York City home to the bizarre Dr. Strangedog.
As Dr. Strangedog and Bruiser activated the Pet-O-Matic Ray, Slimer overheard them from the mansion's storm drain. He flew up and infiltrated the mansion. Slimer was able to get rid of them but was unable to turn off their doomsday device. Instead, Slimer deflected its ray back onto the mansion and completely destroyed it all.
- The welcome mat isn't very welcoming. It says, "Go Away"
- A portrait of Professor Dweeb hung in the hallway