Harold is first known as a writer in National Lampoon's Animal House. Harold directed National Lampoon's Vacation in 1983, starring Chevy Chase and Beverly D'Angelo. Harold's daughter Violet Ramis had a minor role in the movie. As Randy Quaid/Eddie Johnson's daughter in the movie Daisy Mable Johnson.
Harold is best known for his work on Meatballs, Caddyshack, Year One, Ghostbusters, Groundhog Day, and Stripes etc.
On February 24th, 2014, Mr. Ramis passed away due to complications from a rare disease Autoimmune inflammatory vasculitis, a condition he battled for four years. Ramis died Monday morning in his Chicago-area home and is survived by his wife, Erica Mann Ramis, three children and two grandchildren. 
- In The Real Ghostbusters episode "Take Two", Winston mentions Harold Ramis' last name while reading off the cast of the movie being made about the Ghostbusters. 
- On page 12 of Ghostbusters Volume 2 Issue #1, H. Ramis is listed as one of the authors of the technical report.
- In the Ghostbusters: Mass Hysteria hard cover collection, on page five, Ramis is referenced in Dan Aykroyd's introduction.
- In Ghostbusters: Get Real Issue #3, page 14, an eight pin board in the Proton Pack is named after Ramis. 
- A bust of Harold Ramis makes a cameo in Ghostbusters (2016 Movie). Ramis' bust is outside of Erin Gilbert's office at Columbia University. When Dean Harold Filmore was about to leave then said, "Never mind." a second time, the bust is in view.
- ↑ CNN 2/24/14
- ↑ Winston Zeddemore (2009). The Real Ghostbusters - "Take Two" (1986) (DVD ts. 06:20-06:24). Time Life Entertainment. Winston says: "Murray...Aykroyd...Ramis. What's that? A law firm?"
- ↑ Ray Stantz (2015). IDW Comics- "Ghostbusters: Get Real Issue #3" (2015) (Comic p.14). Ray says: "It was a snap once we upgraded the Ramis Boards from a six-pin to an eight!"