Harold is first known as a writer in National Lampoon's Animal House. Harold directed National Lampoon's Vacation in 1983, starring Chevy Chase and Beverly D'Angelo. Harold's daughter Violet Ramis had a minor role in the movie. As Randy Quaid/Eddie Johnson's daughter in the movie Daisy Mable Johnson.
Harold is best known for his work on Meatballs, Caddyshack, Year One, Ghostbusters, Groundhog Day, and Stripes etc.
On February 24th, 2014, Mr. Ramis passed away due to complications from a rare disease Autoimmune inflammatory vasculitis, a condition he battled for four years. Ramis died Monday morning in his Chicago-area home and is survived by his wife, Erica Mann Ramis, three children and two grandchildren. 
- On page 12 of Ghostbusters Volume 2 Issue #1, H. Ramis is listed as one of the authors of the technical report.
- In the Ghostbusters: Mass Hysteria hard cover collection, on page five, Ramis is referenced in Dan Aykroyd's introduction.