The first encounter of Mayhem was from Fernando which was a attack. Mayhem came out of a vent and started tossing him around the room. The only reason he survived was that Jonathan the Theater Manager scream, which scared the creature off. The Ghostbusters arrived on the scene and started investigating the scene. Abby found a Hyper-Ionization Device, which most likely attracted and energized Mayhem. Patty then has a confrontation with a mannequin that was possessed by Mayhem. Patty meet up with the other Ghostbusters where the device was found, with the possessed mannequin right behind her. The mannequin breaks through the door, and then faces the gGhostbusters with its joints glowing red. The Ghostbusters fire on the mannequin and after a few seconds the mannequin breaks apart revealing the true form of Mayhem. Mayhem flees to the hall, and flies down the hall as the Ghostbusters chase it and firing at will. It then went up through a vent.
Mayhem then appeared on stage with the band "Beasts of Mayhem", which had thought it was a stage effect. Ultimately a few moments later the beast flew and threw the lead singer into a stack of speakers. The Ghostbusters then come in on stage from the backstage. They start firing away again, this time in the concert hall, hitting some of the decor. Then two of the Ghostbusters, Abby and Patty leave the stage to hunt down the ghost. After Patty's fall, she gets up but finds that Mayhem is on her shoulders. She tries to walk it off and Abby decides to fire at it, the other two Ghostbusters join her beam. It gets off Patty's back and then Patty fires at it too. Jillian pulls the Ghost Trap off her proton packs bottom and activates it. Everyone steers it towards the trap, and it goes in.
During the battle at Times Square he attacks Abby, lifting her off the ground and carrying her for a distance before Erin shoots a proton beam at him. He later attacks Jillian, but Patty is ready for him with her Ghost Chipper which takes care of Mayhem.
- Mayhem is the first and only ghost shown captured by a ghost trap in the the film.
- Paul Feig likens Mayhem to more of a 'demon-gargoyle kind of other-worldly thing' that comes from a deeper part of the unknown. 
- Mayhem manifesting at a heavy metal concert was intended to be a funny coincidence. 
- On February 14, 2016, photos of Mattel's 6" inch figures posted first teased Mayhem as a red demonic entity. 
- On February 15, 2016, more photos of Mayhem toy appeared. 
- ↑ EMPIRE Online "Empire Podcast: Ghostbusters Spoiler Special with Paul Feig" 19:01-19:13 7/27/16 Paul Feig says: "Yeah, to me, he's more kind of like a demon... gargoyle kind of other worldly thing but it does have a dragon-ish quality to him."
- ↑ EMPIRE Online "Empire Podcast: Ghostbusters Spoiler Special with Paul Feig" 19:20-19:33 7/27/16 Paul Feig says: "I like the idea of as he's energizing things. He's pulling from weirder weirder places and deeper parts of the unknown, so this one comes up and also just comedically I like the idea at this heavy metal concert he'd show up and everyone would think it's part of the show."
- ↑ Toy Ark "Toy Fair 2016 – Mattel Ghostbusters 2016" 2/14/16
- ↑ Ghostbusters News "Mattel reveals a kid sized Ghostbusters proton pack + more!" 2/15/16