For the Hart Island incident, Special Agent Ortiz equipped herself with the pistol. Not one to ruminate on the sudden appearance of thousands ghosts, Ortiz shot the controlling entity, Vigo, right in the face with her Proton Pistol.
- The Proton Pistol is visually based on the Proton Pistol from Extreme Ghostbusters.
- In the script, Erik Burnham called for another Proton Pistol for Melanie and Dan Schoening modified the design himself. 
- On Cover A of Ghostbusters 101 #6, Melanie Ortiz has the Proton Pistol.