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The Relic of Nilhe is a spherical artifact that had the power to resurrect Dumazu the Destroyer.
In 2010 B.C., the Relic of Nilhe was impossibly broken into four pieces and scattered across the land just before the death of Dumazu. It was still the key to Dumazu's resurrection. If the Relic were ever made complete, it could revive the dead god.
In 1954 A.D., a shard was discovered in New York by two construction workers, one named Jimmy. The shard was turned over to the America Museum of Natural History where it remained on display for decades. In present day New York, Janosz Poha stole the shard from the museum and handed it over to Ismael in exchange for getting Dana Barrett. Ismael did not honor the deal and used the shard to assume control of Parkview. 
When the junior team of the Ghostbusters arrived at the Parkview, Ismael posed as "Dr. Michael Tesmon" and gave them a cover story that the shard was confiscated off a new patient. Once the staff brought it out into the open, the hospital was inundated with entities. 
When the junior team brings all four shards to the Firehouse, they combine on their own power. All attempts to destroy it failed so the junior team returned to the Parkview to question Dr. Tesmon. Ismael takes the Relic and chants Dumazu's name. Dumazu takes everyone through a portal to another dimension. Ismael, Dumazu, and the Relic are destroyed in the battle's finale.
The main power of the Relic is to resurrect Dumazu. The shards all have a magnetic attraction to each other and awakens paranormal forces dedicated to preventing Dumazu's resurrection. Among this group, the Subway Smasher, Nocnitsa, and Tomb Effigy possess one shard each. When one shard is near another, it glows intensely. Even in close proximity only, the shards emanate remarkable destructive potential. 
- On page nine of Ghostbusters Issue #13, the Relic of Nilhe and one of its shards appears on photos above Ismael.
- On page four of Ghostbusters Issue #16, the Relic of Nilhe appears as one of the ornaments hanging on the Christmas Tree.