Paul Smart created the robot by stealing a trap containing a recently-captured ghost and photographing blueprints for the P.K.E. Meter, Ghost Trap, and Proton Pack. The Robo-Buster can fly and has Proton Cannons built in its arms. The strategic advantage it had over the Ghostbusters is that its Proton Streams not only caught ghosts, it also completely destroyed them if they were in the streams long enough. Because of this, the Robo-Buster did not need a trap or a Containment Unit. In actuality, it was disassembling their essence, which later recombined themselves into one giant ectoplasmic gestalt. Tired of Robo-Buster's fame, Janine Melnitz confronted Smart but Robo-Buster destroyed Slimer. The Ghostbusters demanded Robo-Buster's blaster schematics in order to figure out how to bring Slimer back. 
Robo-Buster was no match against the Spectral Mass and was possessed by one of the vengeful entities. The Ghostbusters deactivated the robot and wrangled the ghost out. Egon quickly reversed the blaster circuits to negative ionization (which the Ghostbusters' Proton Packs also used) and aid them in trapping the mass.  During the firefight, Robo-Buster was fatally damaged when the mass punched it.
Being a robot, Robo-Buster didn't have much in the way of a personality. While it will address the ghosts before it "destroys" them, this is more likely a pre-programmed response. In its commercial it proclaims "I am not afraid of any ghosts!" However, this is also likely to be programming as well, and not indicative of a personality. At best Robo-Buster is simply an automaton, more equipment than character. In spite of this, Peter comments "he had a heart after all" after Robo-Buster shuts down.
- Robo-Buster's slogan, "I am not afraid of any ghosts" is a paraphrasing of a line in Ray Parker, Jr.'s theme from the 1st Ghostbusters movie: " I ain't 'fraid of no ghosts!"
- According to Smart, it comes with 600,000 Volts of Protons, 20 MB of onboard memory and has an energy sensor radius of 5 miles.  
- The "Robo-Buster" script lists Robo-Buster's height as seven feet and requests his design to not be just like Robo-Cop. 
- There was an issue of the NOW comic book that had Egon build a similar robot named Ecto-X. Unlike Robo-Buster, Ecto-X used more traditional methods of ghostbusting and had a trap built into its chest. Eventually, Ecto-X started overshadowing the popularity of the Ghostbusters. Egon learned his lesson after a Computer Demon possessed Robo-Buster and imprisoned them in the trap. Slimer freed the Ghostbusters and they destroyed Ecto-X in order to trap the ghost. It should be noted that Egon erroneously refers to Ecto-X as Robobuster in one panel. 
- On page 19 of Ghostbusters Volume 1 Issue #14, Robo-Buster makes a non-canon cameo as miniature model on the table. Its quote "unlawful entity" is above the Pig Snouted Demon's photo. The anti-Ghostbusters logo seen in the television advertisement is also on the board near the Robo-Buster model.
- On page four of Ghostbusters Volume 1 Issue #15, Robo-Buster makes a non-canon cameo on the Omni magazine cover.
- On page 20 of Ghostbusters Volume 2 Issue #5, one of Robo-Buster's claws makes a non-canon cameo at the end of the stick Egon Spengler uses.
- On page 43 of the Ghostbusters: Get Real trade paperback, one portal features three Robo-Busters.
- ↑ Robo-Buster (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 06:30-06:33). Time Life Entertainment. Robo-Buster says: "I am Robo-Buster, a fully automated mobile, ghost eradication unit."
- ↑ Paul Smart (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 06:17-06:21). Time Life Entertainment. Paul says: "From Grossjuck Industries, Robo-Buster X-1."
- ↑ Ray Stantz (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 13:12-13:19). Time Life Entertainment. Ray says: "What we need are the designs for Robo-Buster's blaster circuits then we can figure out how to reverse the process and bring Slimer back."
- ↑ Egon Spengler (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 18:30-18:35). Time Life Entertainment. Egon says: "I'll need your Proton Packs. I'm going to convert the robot's throwers into negative ionizing ones."
- ↑ Robo-Buster (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 06:36-06:42). Time Life Entertainment. Robo-Buster says: "I am armed with 600,000 volts of proton stream firepower and 20 megabytes of on-board memory."
- ↑ Robo-Buster (2009). The Real Ghostbusters - "Robo-Buster" (1988) (DVD ts. 06:50-06:52). Time Life Entertainment. Robo-Buster says: "My energy sensors have an effective radius of five miles."
- ↑ Moss, Francis (2009). The Real Ghostbusters Complete Collection Volume Four Disc Five, "Robo-Buster" Script p. 11. CPT Holdings, Inc.