Sigourney Weaver is the actress who played Dana Barrett in both films. She had originally turned down an offer to reprise her role Ghostbusters: The Video Game. Allegedly she tried to come aboard upon learning Bill Murray had agreed to the project, but development was too far along by that point.
In addition to her role as Dana Barrett in the Ghostbusters films, Sigourney Weaver is well known for her roles as Ellen Ripley in the Alien films.
- In the "Visitation" back up story from Ghostbusters Volume 2 Issue #7 and Ghostbusters Volume 2 Issue #8, the teacher is visually based on Sigourney Weaver.