Times Square is a location in New York City's Manhattan. It serves as a major intersection but is famous as a hub for the Broadway theater district and entertainment in general.
In 1984, after the Containment Unit was shut down, the possessed Louis Tully wandered near the Embassy Theater and WienerWald Austrian Restaurant. He paused near the George M. Cohan Statue at the same time the released ghosts flew past Dana Barrett's balcony and caused an explosion.
During his second coming, Gozer manifested and marched to Times Square, again in the form of Stay Puft Marshmallow Man. When the Ghostbusters defeated him, he exploded and his remains splattered all over the street below.
Legion Mini SeriesEdit
In 2004, the Ghost Legion attacked several parts of New York City, including Times Square.
IDW Ongoing SeriesEdit
In the late 1970s, the ghost of Pappy Sargassi manifested at several branches of his Sargassi's seafood restaurant, including the Times Square outlets before settling at the Sedgewick Hotel.  Before the events of the "Displaced Aggression" incident, Rachel Unglighter was present in Times Square at 6 pm for unspecified reasons.  A few years later, the Ghostbusters confronted the Gozerian Terror Bear in Times Square after it caused severe property damage near the Weaver Theater. It was easily defeated with a few Boson Darts but as Ray Stantz retrieved his Megatrap from Ecto-1a, he was kidnapped by Idulnas.
The New Ghostbusters were called to "something hinky" in Midtown Manhattan. They trapped something in the Duffy Square section in the northern triangle of Times Square. At 6 pm, the Grendel manifested and chased after Janine Melnitz. Just after she trapped it, the Ghostbusters appeared after accidentally blowing up one of the Draugar. On New Year's Eve, Rodefhiri stood on the roof of the Times Tower and fed on children down below in Times Square by draining their ambient mental energy and adding it to his own Psychkinetic reserves. The Ghostbusters intervened and trapped him at midnight.
As the 101 Cadets neutralized Manhattan's Ley Lines with positively charged Psychomagnotheric Slime, a two-block perimeter was set up in Times Square and the two teams of Ghostbusters positioned themselves on two building rooftops parallel to each other in the likelihood they had be in pack range to wrangle the Bronx Spook from the dimensional breach. Abby Yates and Jillian Holtzmann drove the Ultimate Mobile Trap to Duffy Square and took their position. Abby activated the trap and it soon pulled the ghost through a breach from between dimensions but it resisted. They opened fire and finished pulling it through the breach. It took a swipe at the rooftop teams but was fully captured. However, the breach remained. In order to seal it and catalyze the separation of their dimensions, they crossed the streams on the breach and came nearly close to a full protonic reversal.
A Tommy-gun Ghost manifested in a toy store in Times Square and emitted bursts of ectoplasm in the form of bullets. The Ghostbusters were called in and deal with the ghost. After exchanging fire, the bust moved outside where the ghost took a reporter hostage. Peter trapped the ghost and saved the reporter, but she was drenched in slime.
- During principal photography for the first movie, there were plans to have the Ghostbuster news flash displayed in Times Square but it was cancelled due to rain. The film crew never had to time to go back and film the shot because of the tight production schedule. 
- On page 9 of Tobin's Spirit Guide, it is revealed there are Sargassi's outlets in Times Square.
- On the Regular Cover of Ghostbusters 101 #3, Times Square is marked on the map.
- On page 11 of Ghostbusters 101 #6:
- The Coming Soon advertisement references William T. Deutschendorf and Henry J. Deutschendorf II, who portrayed Oscar in Ghostbusters II and went into a career in martial arts.
- In panel 2, the sign references Granny's Yum Yum Candy from The Real Ghostbusters episode "Egon's Ghost".
- In panel 4, Abby and Holtzmann stop at Duffy Square. It was previously seen in Volume 2 Issue #3.
- In panel 4, on the signs on the left:
- Ghostbusters fans, Des O'Gorman and his fiance Jolanta Pawlicka. 
- Stay Puft Marshmallows ad from the first movie.
- Right of the Stay Puft Marshmallows is the Time ad from The Real Ghostbusters episode "Three Men and an Egon".
- Above the 'we have our packs...' bubble is the Granny Candy mascot head seen under the Yum Yum sign in The Real Ghostbusters episode "Egon's Ghost".
- Below the 'we have our packs...' bubble is El's Diner from The Real Ghostbusters episode "The Man Who Never Reached Home".
- Below the El's Diner sign is Tri Kuppa Bro from The Real Ghostbusters episode "The Old College Spirit".
- Right of Tri Kuppa Bro is ABS Studios and its eye icon from The Real Ghostbusters episode "Egon on the Rampage".
- In panel 4, on the signs in the center:
- At the top is WUGH-FM Studio, the radio station from The Real Ghostbusters episode "Mr. Sandman, Dream Me a Dream".
- Under WUGH is EBS Broadcasting from IDW's Mars Attacks The Real Ghostbusters.
- Under EBS is Melon Spirits, a sign seen before in past comics such as Volume 2 Issue #20.
- Under Melon is Blody from The Real Ghostbusters episode "The Halloween Door".
- Under Blody is Caste also from "The Halloween Door".
- Under Caste, the dancing figures are from the right half of the Magic Window logo, as seen on The Real Ghostbusters VHS tapes released in the U.S.A.
- Right of Blody is Toy Tower from The Real Ghostbusters episode "Busters in Toyland"
- In panel 4, on the signs on the right:
- In the upper right corner is the Pequod's logo.
- Under Pequod's is the Movieland Theater, seen in the second montage of Ghostbusters II
- Movieland's is playing "White Fish" which might be a nod to the previous issue, as the Ghostbusters captured a ghost resembling Moby Dick.
- The yellow sign with kanji characters below the Movieland sign are the "Eat In Take Out" sign above the garage of Zhu's Authentic Hong Kong Food from the 2016 movie.
- On page 13 of Ghostbusters 101 #6, in panel 6, on the left, the GI sign references Grossjuck Industries from The Real Ghostbusters episode "Robo-Buster".
- On page 14 of Ghostbusters 101 #6:
- In panel 5 is Zhu's Authentic Hong Kong Food from the 2016 movie.
- In panel 5, on the right is Ninja Dry Cleaners from the Teenage Mutant Ninja Turtles 1987 animated series "Turtle Tracks".
- In panel 5, under the Ninja Dry Cleaners sign is another Sony sign.
- In panel 5, the blue sign above Abby's elbow is Molta from the Extreme Ghostbusters episode "Darkness at Noon, Part 1".
- In panel 5, on the far right, Bright Wave High Tech Industries is from the Extreme Ghostbusters episode "Heart of Darkness".
- In panel 5, below Bright Wave is Hasty Pastry Bakery from the Real Ghostbusters episode "The Joke's on Ray".
- In panel 5, below Hasty Pastry is IDW Publishing.
- IDW Comics
- Insight Editions
- IDW Comics
- Panic in Times Square Level (realistic version)
- Panic in Times Square Level (stylized version)
- Times Square (Mission)
- ↑ Narrator (2016). Insight Editions- "Tobin's Spirit Guide" (2016) (Book p.9). Paragraph reads: "Sargassi's ghost began to manifest at different branches of Sargassi's restaurants in the late 1970s, including the Brooklyn, Staten Island, and Times Square outlets, before finding a permanent home in the dining room of the branch located in the Sedgewick Hotel lobby."
- ↑ Entity Datasheet (2012).IDW Comics- "Issue #6" (2012) (Comic p.21).
- ↑ Shay, Don (November 1985). Making Ghostbusters, p. 93 annotation. New York Zoetrope, New York NY USA, ISBN 0918432685. Paragraph reads: "Arrangements had been made with the familiar Times Square landmark to display the Ghostbusters news flash, but the shot had to be cancelled on the day of shooting due to rain. With their critically tight production schedule, particularly during the New York location shoot, the film crew was unable to return for the shot."
- ↑ Ghostheads United Des O'Gorman post 3/14/18
- ↑ Narrator (2016). Insight Editions- "Tobin's Spirit Guide" (2016) (Book p.49). Paragraph reads: "With so many revelers gathered in Times Square, Rodefhiri became so powerful that we needed to use more than one trap to capture him."