Twinkie's Witch is a witch who seems to enjoy pranks and owns a familiar named Twinkie.
On the night of a full moon, the witch pulled a prank on two helicopter pilots. A gust of wind knocked Twinkie off the broom. The cat fell on top of a pizza delivered to Slimer. The witch scoured all of New York City for her lost cat. After casting a location spell, she gleaned an imperfect image of the Firehouse. She arrived at the Firehouse when she noticed it was snowing only in that area. The witch teamed up with Louis Tully, Ray Stantz, and Egon Spengler to find Twinkie and get past Slimer's wishes. She took Twinkie back, admitted she wasn't all that bad, and flew away.