The Uptown Hotel is a new ritzy hotel that opened up in Manhattan.
Slimer and Bud came up with a plan to get rid of Morris Grout by stealthily informing him of an opening at the Uptown for a manager. Morris took the bait and became the Uptown's manager. However, Morris' vacant position was replaced by Professor Dweeb. Slimer, Bud, and Fred ventured to the Uptown to get Morris back. Slimer began scaring guests of the Uptown and Morris became overwhelmed with a flood of complaints. The plan paid off and Morris quit his job to return to the Sedgewick Hotel.
- The newspaper ad lists the Uptown's phone number as 1-800-555-1212, a number often associated with directory assistance.
- On page 13 of Ghostbusters Volume 2 Issue #3, the Uptown Hotel makes a non-canon cameo in the background.